Fresh from their 16-14 win against Wales at Twickenham in round two, England have brought in Ollie Lawrence to the midfield for the Calcutta Cup fixture, along with fellow backs George Furbank and Danny Care - who will win his 99th Test cap - whilst Ellis Genge and Dan Cole are restored to the front row.
Two additions to the bench see George Martin and Ben Spencer included.
ENGLAND XV: 15. George Furbank, 14. Tommy Freeman, 13. Henry Slade, 12. Ollie Lawrence, 11. Elliot Daly, 10. George Ford - vice captain, 9. Danny Care, 1. Ellis Genge - vice captain, 2. Jamie George - captain, 3. Dan Cole, 4. Maro Itoje - vice captain, 5. Ollie Chessum, 6. Ethan Roots, 7. Sam Underhill, 8. Ben Earl REPLACEMENTS 16. Theo Dan, 17. Joe Marler, 18. Will Stuart, 19. George Martin, 20. Chandler Cunningham-South, 21. Ben Spencer, 22. Fin Smith, 23. Immanuel Feyi-Waboso