With Cameron Woki released back to his club and Posolo Tuilagi not at full fitness, France bring Thibaud Flament back into the second row to partner Emmanuel Meafou.
Captain Grégory Aldritt has recovered from the injury suffered against Scotland, while Julien Marchand is preferred to Peato Mauvaka in the front row.
With Matthieu Jalibert injured, the fly-half position will again be taken by Thomas Ramos, with Leo Barré making his debut at fullback. Nolann Le Garrec takes over from Maxime Lucu at scrum-half.
Partnering Gaël Fickou in midfield is former U20 world champion Nicolas Depoortère, while Louis Bielle-Biarrey returns to the back three.
France XV
15 Léo Barré
14 Damian Penaud
13 Gaël Fickou
12 Nicolas Depoortère
11 Louis Bielle-Biarrey
10 Thomas Ramos
9 Nolann Le Garrec
1 Cyril Baille
2 Julien Marchand
3 Uini Atonio
4 Thibaud Flament
5 Emmanuel Meafou
6 François Cros
7 Charles Ollivon
8 Grégory Alldritt (capitano)
Replacements:
16 Peato Mauvaka
17 Sébastien Taofifénua
18 Georges-Henri Colombe
19 Romain Taofifénua
20 Alexandre Roumat
21 Paul Boudehent
22 Maxime Lucu
23 Yoram Moefana