The scrum-half and fly-half respectively have never started a Test match together, and have been named as part of Gonzalo Quesada's first ever team announcement as Italy head coach. Saturday's match at the Stadio Olimpico in Rome will kick off at 14:15 GMT, live on ITV. Play Six Nations Fantasy Rugby by clicking here.
Italy team 15 Tommaso Allan (Perpignan, 79 caps)
14 Ange Capuozzo (Stade Toulousain, 16 caps)
13 Juan Ignacio Brex (Benetton Rugby, 30 caps)
12 Tommaso Menoncello (Benetton Rugby, 12 caps)
11 Monty Ioane (Lione 25 caps)
10 Paolo Garbisi (Montpellier, 31 caps)
9 Alessandro Garbisi (Benetton Rugby, 7 caps)
8 Lorenzo Cannone (Benetton Rugby, 16 caps)
7 Michele Lamaro (c) (Benetton Rugby, 33 caps)
6 Sebastian Negri (Benetton Rugby, 52 caps)
5 Federico Ruzza (Benetton Rugby, 49 caps)
4 Niccolò Cannone (Benetton Rugby, 36 caps)
3 Pietro Ceccarelli (Perpignan, 31 caps)
2 Gianmarco Lucchesi (Benetton Rugby, 17 caps)
1 Danilo Fischetti (Zebre Parma, 36 caps)
Replacements
16 Giacomo Nicotera (Benetton Rugby, 18 caps)
17 Mirco Spagnolo (Benetton Rugby, esordiente)
18 Giosuè Zilocchi (Benetton Rugby, 16 caps)
19 Andrea Zambonin (Zebre Parma, 3 caps)
20 Edoardo Iachizzi (Benetton Rugby, 6 caps)
21 Manuel Zuliani (Benetton Rugby, 17 caps)
22 Stephen Varney (Gloucester, 24 caps)
23 Lorenzo Pani (Zebre Parma, 5 caps)