Peter O’Mahony captains Ireland for the Round 4 visit to London, with Hugo Keenan returning to the starting XV after recovering from injury.
Keenan joins Calvin Nash and James Lowe in the Ireland back three, with Bundee Aki and Robbie Henshaw continuing their midfield partnership.
Jack Crowley and Jamison Gibson-Park are retained as the half-back pairing.
In the pack, Andrew Porter, Dan Sheehan and Tadhg Furlong are in the front row, with Joe McCarthy and Tadhg Beirne named in the engine room.
Captain O’Mahony is at blindside flanker, Josh van der Flier is at openside and Caelan Doris completes the starting XV at number eight.
Ireland team to play England: 15. Hugo Keenan (UCD/Leinster)(38), 14. Calvin Nash (Young Munster/Munster)(4) , 13. Robbie Henshaw (Buccaneers/Leinster)(70) ,12. Bundee Aki (Galwegians/Connacht)(54) , 11. James Lowe (Leinster)(29) , 10. Jack Crowley (Cork Constitution/Munster)(12) , 9. Jamison Gibson-Park (Leinster)(33) , 1. Andrew Porter (UCD/Leinster)(62) , 2. Dan Sheehan (Lansdowne/Leinster)(24) , 3. Tadhg Furlong (Clontarf/Leinster)(74) , 4. Joe McCarthy (Dublin University/Leinster)(8) , 5. Tadhg Beirne (Lansdowne/Munster)(48) , 6. Peter O’Mahony (Cork Constitution/Munster)(captain)(103) , 7. Josh van der Flier (UCD/Leinster)(60) , 8. Caelan Doris (St Mary’s College/Leinster)(39)
Replacements: 16. Ronan Kelleher (Lansdowne/Leinster)(29) , 17. Cian Healy (Clontarf/Leinster)(127) , 18. Finlay Bealham (Buccaneers/Connacht)(38) , 19. Iain Henderson (Academy/Ulster)(80) , 20. Ryan Baird (Dublin University/Leinster)(18) , 21. Jack Conan (Old Belvedere/Leinster)(44) , 22. Conor Murray (Garryowen/Munster)(114) , 23. Ciaran Frawley (UCD/Leinster)(3)
