Second row Posolo Tuilagi and blindside flanker Paul Boudehent are the new faces in Fabien Galthié's starting team.
France are targeting their second win of the Championship in this third-round match, which will be crucial to their hopes of keeping pressure on the undefeated Ireland and England.
France XV: 15 Thomas Ramos, 14 Damian Penaud, 13 Gaël Fickou, 12 Jonathan Danty, 11 Louis Bielle-Biarrey, 10 Matthieu Jalibert, 9 Maxime Lucu, 1 Cyril Baille, 2 Peato Mauvaka, 3 Uini Atonio, 4 Cameron Woki, 5 Posolo Tuilagi, 6 Paul Boudehent, 7 Charles Ollivon (c), 8 François Cros.
Replacements: 16 Julien Marchand, 17 Sébastien Taofifenua, 18 Dorian Aldegheri, 19 Romain Taofifenua, 20 Alexandre Roumat, 21 Esteban Abadie, 22 Nolann Le Garrec, 23 Yoram Moefana