Captain Dafydd Jenkins is named at blind-side flanker with Will Rowlands making his first start of the 2024 Guinness Men's Six Nations alongside Adam Beard in the second row.
Hooker Ryan Elias starts his second match of this Championship.
Joe Roberts will win his second senior international cap on the weekend, partnering Owen Watkin in the midfield.
Among the replacements hooker Elliot Dee is in line to win his 50th cap for Wales from the bench. Gareth Davies is also named in the match day 23 as scrum half cover.
Wales team to face France
15. Cameron Winnett (Cardiff Rugby – 3 caps); 14. Josh Adams (Cardiff Rugby – 57 caps); 13. Joe Roberts (Scarlets – 1 cap), 12. Owen Watkin (Ospreys – 37 caps); 11. Rio Dyer (Dragons – 17 caps); 10. Sam Costelow (Scarlets – 10 caps), 9. Tomos Williams (Cardiff Rugby – 56 caps); 1. Gareth Thomas (Ospreys – 28 caps), 2. Ryan Elias (Scarlets – 41 caps), 3. Keiron Assiratti (Cardiff Rugby – 5 caps); 4. Will Rowlands (Racing 92 – 31 caps) 5. Adam Beard (Ospreys / Gweilch – 54 caps); 6. Dafydd Jenkins (Exeter Chiefs / Caerwysg – 15 caps) (c), 7. Tommy Reffell (Leicester Tigers – 16 caps), 8. Aaron Wainwright (Dragons – 46 caps).
Replacements
16. Elliot Dee (Dragons – 49 caps), 17. Corey Domachowski (Cardiff Rugby – 9 caps), 18. Dillon Lewis (Harlequins – 55 caps), 19. Alex Mann (Cardiff Rugby – 3 caps), 20. Mackenzie Martin (Cardiff Rugby – 1 cap), 21. Gareth Davies (Scarlets – 75 caps), 22. Ioan Lloyd (Scarlets – 5 caps), 23. Mason Grady (Cardiff Rugby – 9 caps)