Ireland ran in five tries in all, with Player of the Match Wafer getting the scoring underway in the 13th minute.
From there, Eve Higgins, Neve Jones, Katie Corrigan and Beibhinn Parsons got in on the action to breath new live into their campaign this Championship.
For Wales, they have now lost all three of their Guinness Women's Six Nations matches so far in 2024 and now prepare to play France next Sunday.
IRELAND START STRONG
Ireland opened the scoring in impressive fashion in the 13th minute following a tense opening at Virgin Media Park.
When a lineout drive came to nothing, Parsons, Brittany Hogan and Jones made it to five metres out, but with space on the left Aoibheann Reilly, Dannah O'Brien and Enya Breen switched play to help Wafer power over the try line, shaking two tackles on the way.
Scott Bemand saw his team's lead double just five minutes later when Higgins got her hands on the ball metres out.
It came as a result of an inspired Reilly run through the Welsh defensive line. After the scrum-half was brought down Sam Monaghan was the next player to take the ball forward, with Higgins going it alone as Wales attempted to reorganise.
Ireland's tally increased again in the 26th minute when Jones was the beneficiary of her team's strong driving maul.
It took 30 seconds from Jones finding Monaghan with the throw for Ireland to get their third try of the afternoon, the crowd in Cork watching on with bated breath as the green jerseys edged closer to the line.
Wales' misfortune continued when Kerin Lake was forced to leave the field with injury after the half-hour mark, with Courtney Keight taking the 33-year-old's place in the backfield.
PRESSURE TELLS
Corrigan's second Ireland try helped lock up the bonus point for the team.
Scarcely two minutes into the second half, the wing charged down Lleucu George's attempt of an exit from Wales 22m and dashed any Welsh hopes of a comeback.
Moments after slotting her fourth conversion of the day, O'Brien had the kicking tee out again to add another three points to the scoreline.
Parsons registered her 15th Guinness Women's Six Nations try as the hour mark peered into view.
After turning the ball over at the lineout, Ireland mounted their latest attack, the ball finding its way out to Wafer who was lurking out wide.
Like for her own try the flanker beat the first defender, but instead of going it alone on this occasion, offloaded to Parsons, who planted a hand on the chest of Jenny Hesketh before accelerating away to score.
CAUSE FOR WELSH OPTIMISM
As the game wore on and changes were made, Gwennan Hopkins' debut seemed to ignite a late resurgence for Wales.
The young Cardiff Rugby flanker scored her team's only try of the afternoon in the 65th minute.
It came in no short part thanks to the free running of Carys Cox, however the 19-year-old launched another attack as Wales found themselves consistently in Irish territory.
That growing confidence was apparent as Cox crossed the try line herself, however Kayleigh Powell's inside pass to the wing was judged to have drifted forwards.