Head coach Scott Bemand has brought in co-captain Edel McMahon to the back row.
The front row remains the same with Linda Djougang and Christy Haney packing down either side of Neve Jones.
Dorothy Wall partners Sam Monaghan in the second row while Aoife Wafer moves across the back row with McMahon coming in at 7 and Brittany Hogan again named at 8.
Dannah O’Brien is at fly-half with Aoibheann Reilly at scrumhalf. Enya Breen and Eve Higgins make up the centre partnership and the back three remains unchanged with Béibhinn Parsons, Katie Corrigan and Lauren Delany all set to start.
Following the record attendance at the RDS against Italy in round two, and with 5,500 tickets already sold for this weekend, another large crowd is expected in Cork.
Ireland team to face Wales
15. Lauren Delany (Sale Sharks/IQ Rugby); 14. Katie Corrigan (Old Belvedere RFC/Leinster); 13. Eve Higgins (Railway Union RFC), 12. Enya Breen (Blackrock College RFC/Munster); 11. Béibhinn Parsons (Blackrock College RFC/Connacht); 10. Dannah O’Brien (Old Belvedere RFC/Leinster), 9. Aoibheann Reilly (Blackrock College RFC/Connacht); 1. Linda Djougang (Old Belvedere RFC/Leinster), 2. Neve Jones (Gloucester-Hartpury), 3. Christy Haney (Blackrock College RFC/Leinster); 4. Dorothy Wall (Blackrock College RFC/Munster), 5. Sam Monaghan (Gloucester-Hartpury) (Co-Captain); 6. Aoife Wafer (Blackrock College RFC/Leinster), 7. Edel McMahon (Exeter Chiefs) (Co-Captain), 8. Brittany Hogan (Old Belvedere RFC/Ulster)
Replacements
16. Clíodhna Moloney (Exeter Chiefs), 17. Niamh O’Dowd (Old Belvedere RFC/Leinster), 18. Sadhbh McGrath (Cooke RFC/Ulster), 19. Fiona Tuite (Old Belvedere RFC/Ulster), 20. Shannon Ikahihifo (Ealing Trailfinders/IQ Rugby)*, 21. Molly Scuffil-McCabe (Leinster), 22. Nicole Fowley (Galwegians RFC/Connacht), 23. Aoife Dalton (Old Belvedere RFC/Leinster) *uncapped
