The roof at the iconic venue will be closed for the occasion, with Italy naming an unchanged pack to the one that featured in the narrow loss to Scotland in round four.
Captain Elisa Giordano packs down at number eight, while in the half-backs Emma Stevanin returns at fly-half. Vittoria Ostuni Minuzzi is this time deployed on the wing, while Beatrice Capomaggi lines up at fullback. Alyssa D'Incà moves in from the wing to outside centre.
On the bench, Lucia Gai is set to become only the second Italian to reach 100 caps - a record previously held solely by Sara Barattin.
Italy team to face Wales
15. Beatrice CAPOMAGGI (Villorba Rugby, 14 caps); 14. Aura MUZZO (Villorba Rugby, 44 caps); 13. Alyssa D’INCÀ (Villorba Rugby, 25 caps), 12. Beatrice RIGONI (Sale Sharks, 74 caps); 11. Vittoria OSTUNI MINUZZI (Valsugana Rugby Padova, 32 caps); 10. Emma STEVANIN (Valsugana Rugby Padova, 14 caps), 9. Sofia STEFAN (Valsugana Rugby Padova, 86 caps); 1. Silvia TURANI (Harlequins, 33 caps), 2. Vittoria VECCHINI (Valsugana Rugby Padova, 25 caps), 3. Sara SEYE (Ealing Trailfinders, 22 caps); 4. Sara TOUNESI (Sale Sharks, 39 caps), 5. Giordana DUCA (Valsugana Rugby Padova, 47 caps); 6. Ilaria ARRIGHETTI (Stade Rennais, 60 caps), 7. Francesca SGORBINI (ASM Romagnat Rugby, 23 caps) 8. Elisa GIORDANO (Capitana, Valsugana Rugby Padova, 66 caps)
Replacements
16. Laura GURIOLI (Villorba Rugby, 10 caps), 17. Gaia MARIS (ASM Romagnat Rugby, 28 caps), 18. Lucia GAI (Valsugana Rugby Padova, 99 caps), 19. Valeria FEDRIGHI (Stade Toulousain, 54 caps), 20. Isabella LOCATELLI (Rugby Colorno, 50 caps), 21. Beatrice VERONESE (Valsugana Rugby Padova, 19 caps), 22. Veronica MADIA (Grenoble Amazones, 50 caps), 23. Francesca GRANZOTTO (Unione Rugby Capitolina, 11 caps)
