Scotland opened their campaign with a first win on Welsh soil in 20 years, before pushing France all the way in Edinburgh in round two of the Guinness Women's Six Nations.
Fullback Chloe Rollie, who has featured from the bench in the first two matches this year, is reinstated to the number 15 jersey at the Hive Stadium, hot off the back of becoming one of the top ten most-capped Scotland women's players of all time.
Hooker Lana Skeldon, like Rollie a product of the Borders, also returns to the starting line-up for the first time this year.
Elsewhere, there is a welcome return for back Francesca McGhie, a nominee for World Rugby's Breakthrough Player of the Year Award in 2023.
Scotland team to face England
15. Chloe Rollie – Loughborough Lightning (63); 14. Rhona Lloyd – GB Sevens / Stade Bordelais (48); 13. Emma Orr – Heriot’s Blues (16), 12. Meryl Smith – Bristol Bears (15); 11. Coreen Grant – Saracens (9); 10 Helen Nelson – (Vice-captain) – Loughborough Lightning (57), 9. Caity Mattinson – Gloucester-Hartpury (20); 1. Leah Bartlett – Leicester Tigers (32), 2. Lana Skeldon – Bristol Bears (67), 3. Christine Belisle – Loughborough Lightning (32); 4. Emma Wassell – Loughborough Lightning (66), 5. Louise McMillan – Saracens (50); 6. Rachel Malcolm (Captain) – Loughborough Lightning (44), 7. Alex Stewart – Corstorphine Cougars (2), 8. Evie Gallagher – Bristol Bears (24)
Replacements
16. Molly Wright – Sale Sharks (20), 17. Elis Martin – Leicester Tigers (7), 18. Elliann Clarke – Bristol Bears (8), 19. Fiona McIntosh – Saracens (uncapped), 20. Rachel McLachlan – Sale Sharks (40), 21. Mairi McDonald – Exeter Chiefs (20), 22. Lisa Thomson - GB Sevens (57), 23. Francesca McGhie – Leicester Tigers (9)