Head coach Bryan Easson has made four changes to the starting XV that took the field against England in round three in Edinburgh.
In the forwards, Molly Wright comes in for Leah Bartlett at loosehead, while Eva Donaldson replaces Emma Wassell in the second row.
in the backs, Francesca McGhie lines up on the wing in place of Coreen Grant, while Lisa Thomson is at inside centre for Meryl Smith.
Scotland are looking for looking for their second win of the Championship in Parma this Saturday, having beaten Wales in Cardiff in the opening round.
Scotland team to face Italy
15. Chloe Rollie – Loughborough Lightning (64); 14. Rhona Lloyd – GB Sevens / Stade Bordelais (49); 13. Emma Orr – Heriot’s Blues (17), 12. Lisa Thomson - GB Sevens (58); 11. Francesca McGhie – Leicester Tigers (10); 10. Helen Nelson – (Vice-captain) – Loughborough Lightning (57), 9. Caity Mattinson – Gloucester-Hartpury (20); 1. Molly Wright – Sale Sharks (21), 2. Lana Skeldon – Bristol Bears (67), 3. Christine Belisle – Loughborough Lightning (32); 4. Eva Donaldson – Leicester Tigers (9), 5. Louise McMillan – Saracens (51); 6. Rachel Malcolm (Captain) – Loughborough Lightning (45), 7. Alex Stewart – Corstorphine Cougars (3), 8. Evie Gallagher – Bristol Bears (25)
Replacements
16. Elis Martin – Leicester Tigers (8), 17. Leah Bartlett – Leicester Tigers (33), 18. Elliann Clarke – Bristol Bears (9), 19. Fiona McIntosh – Saracens (1), 20. Rachel McLachlan – Sale Sharks (41), 21. Mairi McDonald – Exeter Chiefs (21), 22. Meryl Smith – Bristol Bears (16), 23. Coreen Grant – Saracens (10).
