There are four changes to the team. Centre Hannah Jones captains the side and is partnered in the midfield by Hannah Bluck, who makes her first start of this Guinness Women's Six Nations campaign.
Jenny Hesketh, who is one of six players who have made their debut in this tournament, returns at fullback.
Scrum half Keira Bevan partners Lleucu George at half-back, while experienced wing Lisa Neumann is named on the wing.
The same Welsh pack that started against France is once again selected to face the Italians: Sisilia Tuipulotu joins Carys Phillips and Gwenllian Pyrs in the front row, with Abbie Fleming and Natalia John packing down in the Wales engine room. Vice-captain Alex Callender, Alisha Butchers and Georgia Evans make up the Wales back row.
Wing Jasmine Joyce and Kayleigh Powell have returned to GB Sevens duty, while Kerin Lake (shoulder), Bethan Lewis (foot) and Mollie Wilkinson (knee) were unavailable for selection.
Wales team to face Italy
15 Jenny Hesketh; 14 Lisa Neumann; 13 Hannah Jones (captain), 12 Hannah Bluck; 11 Carys Cox; 10 Lleucu George, 9 Keira Bevan; 1 Gwenllian Pyrs, 2 Carys Phillips, 3 Sisilia Tuipulotu; 4 Natalia John, 5 Abbie Fleming; 6 Alisha Butchers, 7 Alex Callender (vice-captain), 8 Georgia Evans
Replacements
16 Kelsey Jones, 17 Abbey Constable, 18 Donna Rose, 19 Kate Williams, 20 Gwennan Hopkins, 21 Sian Jones, 22 Niamh Terry, 23 Nel Metcalfe
