Grand Slam winners Ireland are in South Africa for the first meeting between the sides since last year’s World Cup group stage classic while England take on New Zealand in Dunedin.
Wales, Scotland and France are also in action and the kick-off times (in BST) mean you don’t have to miss a minute of the action – in chronological order, here’s all you need to know…
NEW ZEALAND V ENGLAND (8.05AM)
England last faced the All Blacks in November 2022 in what turned in to an Autumn Nations Series classic at Twickenham, the hosts scoring three tries in the final eight minutes to fight back from 25-6 down and salvage a 25-25 draw.
They have not won a Test in New Zealand since 2003 and a new-look All Blacks lie in wait for this tour, with coach Scott Robertson and captain Scott Barrett both set for their first games in their new roles.
England’s two changes from last weekend’s impressive win in Japan come in the front row, with Will Stuart and Joe Marler coming in – Dan Cole could match Jason Leonard’s 114 caps if he comes off the bench. Replacements Fin Baxter and Ollie Sleightholme could make their international debuts.
Player to watch: How Immanuel Feyi-Waboso fares on his first clash against the All Blacks will be fascinating to see. The fearless Exeter Chiefs wing has taken everything in his stride during his rapid rise so far and will relish the challenge.
What they said: England captain Jamie George said: "It's been bubbling away nicely and if we apply ourselves, the way that I know that we can and the way we have this week, it could be a very special week for us.
England: 15. George Furbank, 14. Immanuel Feyi-Waboso, 13. Henry Slade , 12. Ollie Lawrence, 11. Tommy Freeman, 10. Marcus Smith, 9. Alex Mitchell, 1. Joe Marler, 2. Jamie George, 3. Will Stuart, 4. Maro Itoje, 5. George Martin, 6. Chandler Cunningham-South, 7. Sam Underhill, 8. Ben Earl
Replacements: 16. Theo Dan, 17. Fin Baxter, 18. Dan Cole, 19. Alex Coles, 20. Tom Curry, 21. Ben Spencer, 22. Fin Smith, 23. Ollie Sleightholme.
AUSTRALIA V WALES (10.45AM)
Warren Gatland faces a familiar rival in Joe Schmidt as Wales take on the Wallabies in Sydney.
Wales were comfortable 40-6 winners when the sides met in the World Cup group stage but have not won since beating Georgia in that competition, and now search for a first win over their hosts in Australia since 1969.
An experimental line-up sees Ben Thomas start at fly-half and wing Josh Hathaway given a debut, while flanker Archie Griffin makes his first international start in the city of his birth.
Player to watch: Hathaway represented England and Wales at under-20 level and now makes his senior debut for the men in red. The Gloucester wing offers an exciting new option and joins experienced campaigner Liam Williams and Rio Dyer in the back three.
What they said: Head coach Warren Gatland said: “We’ve had a good week of preparations here in Sydney and are excited to get out on field.
“There’s a lot of talent within the Australia squad and we know they will want to come out firing."
Wales: 15 Liam Williams; 14 Josh Hathaway, 13 Owen Watkin, 12 Mason Grady, 11 Rio Dyer; 10 Ben Thomas, 9 Ellis Bevan; 1 Gareth Thomas, 2 Dewi Lake (capt), 3 Archie Griffin, 4 Christ Tshiunza, 5 Dafydd Jenkins, 6 Taine Plumtree, 7 Tommy Reffell, 8 Aaron Wainwright.
Replacements: 16 Evan Lloyd, 17 Kemsley Mathias, 18 Harri O'Connor, 19 Cory Hill, 20 James Botham, 21 Kieran Hardy, 22 Sam Costelow, 23 Nick Tompkins.
SOUTH AFRICA V IRELAND (4PM)
A tantalising trip to the home of the world champions is the next test of Guinness Six Nations winners Ireland’s mettle.
Andy Farrell’s side edged a titanic clash 13-8 at the World Cup, which the Springboks bounced back from to lift the trophy.
Farrell has handed Jamie Osborne a debut at full-back in the Olympic-related absence of Hugo Keenan, while Craig Casey starts in place of the injured Jamison Gibson-Park at full-back.
Player to watch: Osborne has started in the no.15 jersey just twice for Leinster and how he copes under the intense high-ball pressure in Pretoria will be key. Farrell is a big fan…
What they said: "He suits the way we play, he's bright, he gets himself on the ball a lot in an organising way,” Farrell said of Osborne.
“His communication is good and he's accurate. He's obviously got nice, soft hands and can play that way but also he can hit a line as well.”
Ireland: 15 Jamie Osborne; 14 Calvin Nash, 13 Robbie Henshaw, 12 Bundee Aki, 11 James Lowe; 10 Jack Crowley, 9 Craig Casey; 1 Andrew Porter, 2 Dan Sheehan, 3 Tadhg Furlong; 4 J McCarthy, 5 Tadgh Beirne; 6 Peter O’Mahony (capt), 7 Josh van der Flier, 8 Caelan Doris.
Replacements: 16 Ronan Kelleher, 17 Cian Healy, 18 Finlay Bealham, 19 James Ryan, 20 Ryan Baird, 21 Conor Murray, 22 Ciaran Frawley, 23 Garry Ringrose.
ARGENTINA V FRANCE (8PM)
Baptiste Serin captains a new-look France team on his first international start since an Autumn Nations Series win over Italy in November 2020.
Debutants Theo Attissogbe, Lester Etien, Antoine Frisch, Oscar Jegou, Jordan Joseph and Hugo Auradou are in from the start, with Mickael Guillard and Lenni Nouchi in line for their bows from the bench.
Antoine Dupont headlines a list of notable absentees as France takes on Los Pumas for the first time since a 29-20 win in November 2021.
Player to watch: Jordan Joseph won World Breakthrough Player of the Year when France won the U20s WC back in 2018 – all while playing up two years. He now gets his chance to shine at No.8.
What they said: "A tour is a growth accelerator," said head coach Fabien Galthie.
"It's a big challenge for us, for the players. It's the best team of the moment, taking into account the context and the choices."
France: 15 Leo Barre; 14 Theo Attissogbe, 13 Emilien Gailleton, 12 Antoine Frisch, 11 Lester Etien; 10 Antoine Hastoy, 9 Baptiste Serin; 1 Oscar Jegou, 2 Jordan Joseph, 3 Judicael Cancoriet; 4 Baptiste Pesenti, 5 David Auradou; 6 Georges-Henri Colombe, 7 Gaetan Barlot, 8 Jean-Baptiste Gros
Replacements: 16 Teddy Baubigny, 17 Sebastien Taofifenua, 18 Demba Bamba, 19 Posolo Tuilagi, 20 Mickael Guillard, 21 Lenni Nouchi, 22 Baptiste Couilloud, 23 Melvyn Jaminet
CANADA V SCOTLAND (10PM)
Scotland open up their four-Test trip across the Atlantic in Ottawa, with Canada the first of a list of opponents also including USA, Chile and Uruguay.
Gregor Townsend has named five debutants in his starting XV, with Matt Currie, Arron Reed, Gus Warr, Max Williamson and Gregor Brown in line for a first taste of international rugby.
Prop Rory Sutherland is the most experienced member of the team with 30 appearances as Scotland face Canada for the first time since 2018, a 48-10 win.
Player to watch: Gus Warr was a key part of Sale Sharks’ run to the Premiership play-offs and will look to get a new-look backline firing.
What they said: Head coach Gregor Townsend said: "There will be a lot of examples over the next few weeks of guys taking their opportunity and being genuine contenders for our Test team that plays South Africa in November."
Scotland: 15 Harry Paterson, 14 Jamie Dobie, 13 Matt Currie, 12 Stafford McDowall, 11 Arron Reed, 10 Ross Thompson, 9 Gus Warr; 1 Rory Sutherland, 2 Dylan Richardson, 3 Elliot Millar Mills, 4 Max Williamson, 5 Glen Young, 6 Gregor Brown, 7 Luke Crosbie, 8 Josh Bayliss.
Replacements: 16 Robbie Smith, 17 Nathan McBeth, 18 Will Hurd, 19 Ewan Johnson, 20 Matt Fagerson, 21 Ben Healy, 22 Kyle Steyn, 23 Ross McCann.
Italy were beaten 33-25 by Samoa in the early hours of Friday morning. Monty Ioane, Louis Lynagh and Paolo Garbisi scored for Italy but the hosts hit back from 10 points down to claim victory.
